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Cell proliferation, differentiation, and apoptosis (programmes cell death) are tightly regulated in healthy tissues by a variety of external signals via membrane-spanning receptors that activate intracellular signal transduction pathways. Some cancer cells acquire genetic mutations that dysregulate these pathways, resulting in malignant cells that uncontrollably proliferate and no longer respond to the signals that normally activate apotosis.1
1 Hanahan D, Weinberg R. Cell. 2000;100(1):57-70
*Afatinib (compound code BIBW 2992) is an investigational compound. Its safety and efficacy has not yet been fully established.
Source for healthcare professionals: www.inoncology.com
* Nintedanib (BIBF 1120), afatinib (BIBW 2992) and volasertib (BI 6727) are investigational compounds. Their safety and efficacy have not yet been fully established.
