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PLK1 and Polo arrest
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PLK1 and Polo arrest

Boehringer Ingelheim

 

Polo-like kinase 1 (PLK1) plays a role in several important steps in the cell cycle,1,2 including:

 

In cancer, PLK1 can be overexpressed. In many tumors, this may correlate with a poor prognosis.2 Inhibition of PLK1, which may result in “Polo arrest,” is a focus of anticancer research.1,3 Polo arrest is a uniquephenotype associated with:

 

1. Schmit TL, Zhong W, Setaluri V, Spiegelman VS, Ahmad N. J Invest Dermatol. 2009;129(12):2843-2853.
2. Strebhardt K, Ullrich A. Nat Rev Cancer. 2006;6(4):321-330.
3. Rudolph D, Steegmaier M, Hoffmann M, et al. Clin Cancer Res. 2009;15(9):3094-3102.

 


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